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Main Title Evaluation of the Developmental Toxicity of Sodium Nitrite in Long-Evans Rats (Journal Version).
Author Roth, A. C. ; Herkert, G. E. ; Bercz, J. P. ; Smith, M. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/390;
Stock Number PB89-101109
Additional Subjects Toxic substances ; Nitrites ; Toxicity ; Hypochromic anemia ; Pregnancy ; Lactation ; Prenatal exposure delayed effects ; Laboratory animals ; Sodium inorganic compounds ; Mortality ; Exposure ; Hematology ; Growth ; Histology ; Pathology ; Liver ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-101109 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Sodium nitrite administered in the drinking water to Long-Evans rats during pregnancy and lactation severely affected arythropoietic development, growth and mortality in their offspring. There were no significant differences between treated and control litters at birth. Thereafter, pups of treated dams on 2 and 3 q NaNO2/L gained less weight, progressively became severely anemic and began to die by the third week postpartum. By the second week postpartum, hemoglobin levels, RBC count, and MCV's of these pups were all drastically reduced compared to controls. Blood smears showed marked anisocytosis and hypochromasia. Gross chylous serum lipemia and fatty liver degeneration were noted. The data presented are consistent with the lactational induction of severe iron deficiency in the neonata.