Record Display for the EPA National Library Catalog


Main Title Learning and Memory Deficits in Rats Following Exposure to 3,3'-Iminodipropionitrile.
Author Peele, D. B. ; Allison, S. D. ; Crofton, K. M. ;
CORP Author NSI Technology Services Corp., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1990
Year Published 1990
Report Number EPA-68-02-4450; EPA/600/J-90/279;
Stock Number PB91-145078
Additional Subjects Toxicity ; Learning disorder ; Memory ; Avoidance learning ; Pain ; Rats ; Smell ; Taste ; Reprints ; Iminodipropionitriles
Library Call Number Additional Info Location Last
NTIS  PB91-145078 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
The effects on learning and memory produced by beta, beta prime-iminodipropionitrile (IDPN) were examined in rats 4 weeks after dosing. IDPN (600 mg/kg) prevented acquisition of a olfactory discrimination task and disrupted performance of passive avoidance conditioning in separate groups of animals. The disruptive effects on passive avoidance conditioning were dosage dependent. Rats from both control and treated groups were then tested using a standard hot-plate test. The results suggest that treatment with IDPN did not produce the observed effects on learning and memory by altering sensitivity to painful, external stimuli. In summary, administration of IDPN is capable of producing profound and long lasting disruption of learning and memory in rats. (Copyright (c) 1990 by Academic Press, Inc.)