| Main Title |
In-vitro screening methods evaluating the neurotoxic potential of pesticides / |
| Author |
Narahashi, Toshio.
|
| CORP Author |
Duke Univ. Medical Center, Durham, N.C. Dept. of Physiology and Pharmacology.;Health Effects Research Lab., Research Triangle Park, N.C. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; Distributed by National Technical Information Service, |
| Year Published |
1976 |
| Report Number |
EPA 600/1-76-005; EPA-68-02-1289 |
| Stock Number |
PB-249 352 |
| OCLC Number |
39759978 |
| Subjects |
Insecticides--Toxicology ;
Neurotoxic agents
|
| Additional Subjects |
Pesticides ;
Toxicity ;
Nerve cells ;
Insecticides ;
Neuromuscular blocking agents ;
Evaluation ;
In vitro analysis ;
Nervous system ;
Abdomen ;
Crayfishes ;
Electrophysiology ;
Experimental data ;
Neurotoxins
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-76-005 |
c.1 |
Headquarters Library/Washington,DC |
02/27/2014 |
| EKBD |
EPA-600/1-76-005 |
|
Research Triangle Park Library/RTP, NC |
02/11/2000 |
| ELBD ARCHIVE |
EPA-600-1-76-005 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-1-76-005 |
|
AWBERC Library/Cincinnati,OH |
08/26/2016 |
| NTIS |
PB-249 352 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
iii, 42 pages : illustrations ; 28 cm. |
| Abstract |
The abdominal nerve cord preparation isolated from the crayfish is far superior to the frog neuromuscular and crayfish neuromuscular preparations for evaluation of neurotoxicity of various pesticides and other environmental agents. Neurotoxicity is manifested as stimulation and/or paralysis of spontaneous discharges of the nerve cords. The techniques involved in this experiment are rather simple, and require only reasonable amounts of conventional electrophysiological equipment. Thus such toxicity evaluation can be performed with a modest amount of expense. More sophisticated and efficient data acquisition systems could be developed using basically the same techniques. |
| Notes |
"Contract no. 68-02-1289." "January 1976." |
