Record Display for the EPA National Library Catalog


Main Title In-vitro screening methods evaluating the neurotoxic potential of pesticides /
Author Narahashi, Toshio.
CORP Author Duke Univ. Medical Center, Durham, N.C. Dept. of Physiology and Pharmacology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; Distributed by National Technical Information Service,
Year Published 1976
Report Number EPA 600/1-76-005; EPA-68-02-1289
Stock Number PB-249 352
OCLC Number 39759978
Subjects Insecticides--Toxicology ; Neurotoxic agents
Additional Subjects Pesticides ; Toxicity ; Nerve cells ; Insecticides ; Neuromuscular blocking agents ; Evaluation ; In vitro analysis ; Nervous system ; Abdomen ; Crayfishes ; Electrophysiology ; Experimental data ; Neurotoxins
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-76-005 c.1 Headquarters Library/Washington,DC 02/27/2014
EKBD  EPA-600/1-76-005 Research Triangle Park Library/RTP, NC 02/11/2000
ELBD ARCHIVE EPA-600-1-76-005 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-1-76-005 AWBERC Library/Cincinnati,OH 08/26/2016
NTIS  PB-249 352 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iii, 42 pages : illustrations ; 28 cm.
The abdominal nerve cord preparation isolated from the crayfish is far superior to the frog neuromuscular and crayfish neuromuscular preparations for evaluation of neurotoxicity of various pesticides and other environmental agents. Neurotoxicity is manifested as stimulation and/or paralysis of spontaneous discharges of the nerve cords. The techniques involved in this experiment are rather simple, and require only reasonable amounts of conventional electrophysiological equipment. Thus such toxicity evaluation can be performed with a modest amount of expense. More sophisticated and efficient data acquisition systems could be developed using basically the same techniques.
"Contract no. 68-02-1289." "January 1976."