||Inhibitation of Benzo(A)Pyrene Monooxygenase by alpha-Naphthoflavone may be Partially Mediated by the Metabolite 9-Hydroxy-alpha-Naphthoflavone.
Nesnow, Stephen ;
Easterling, Robert ;
Bergman, Hinda ;
Roth, Robert ;
||Health Effects Research Lab., Research Triangle Park, NC.
Benzopyrene monooxygenase ;
||Some EPA libraries have a fiche copy filed under the call number shown.
Naphthoflavone (ANF) inhibits beta-naphthoflavon-induced rat liver microsomal benzo(a)pyrene metabolism and is transformed by these microsomes into naphthoflavone metabolites. The authors determined the inhibitory effect on benzo(a)pyrene (B(a)P) metabolism of several of these metabolites and of 6-methoxy-ANF, using beta-naphthoflavone-induced rat liver microsomes. 9-Hydroxy-ANF was the most active inhibitor (I50 = 1.47 micro M) and was metabolized from ANF by these hepatic cimrosomes in concentrations which are inhibitory. Therefore, 9-hydroxy-ANF a microsomal metabolite of ANF, may play a role in the inhibition of B(a)P oxidation by ANF.