Record Display for the EPA National Library CatalogRECORD NUMBER: 6 OF 22
|Main Title||Identification of Cocarcinogens and Their Potential Mechanisms of Action Using C3H10T(1/2)CL8 Mouse Embryo Fibroblasts.|
|Author||Nesnow, Stephen ; Leavitt, Sharon ; Garland, Helen ; Vaughan, T. Owens ; Hyatt, Betty ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Carcinogens ; Toxicology ; Identifying ; Mice ; Reprints ; Fibroblasts ; Fetuses|
The cocarcinogenic action of five agents which increase microsomal mixed-function oxidase activity in vivo was examined in the C3H101/2CL8 transformation assay. The compounds studies were benz(a)anthracene, 5,6-benzoflavone, phenobarbital, pregnenolone-16a-carbon-nitrile, and Aroclor 1254. After a 48-hr pretreatment with the agent, the cells were then treated with benzo(a)pyrene (B(a)P) and the agent for an additional 24hr. This suggests that these agents exert their cocarcinogenic action via increases in the enzyme-mediated pathways of B(a)P metabolism.