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Main Title Genotoxicity and Identification of the Major DNA-Adducts of Aceanthrylene.
Author Nesnow, S. ; Ross, J. ; Mohapatra, N. ; Gupta, R. ; Sangaiah, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Baylor Coll. of Medicine, Houston, TX. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering.
Year Published 1988
Report Number EPA/600/D-88/026;
Stock Number PB88-170071
Additional Subjects Toxicology ; Deoxyribonucleic acids ; Identification ; Genotoxicity ; Aceanthrylene ; Salmonella typhimurium
Library Call Number Additional Info Location Last
NTIS  PB88-170071 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Aceanthrylene (ACE), a cyclopenta-fused polycyclic aromatic hydrocarbon (CP-PAH) derivative of anthracene has been shown to be highly mutagenic in Salmonella typhimurium strain TA98 (1). C3H10T1/2CL8 (C3H10T1/2) mouse embryo fibroblasts have been used to study the metabolism and morphological transforming ability of PAH and several CP-PAH (2-5). The CP-PAH, cyclopenta(cd)pyrene and three of the four possible cyclopenta-benz(a)anthracene isomers were active in morphologically transforming C3H10T1/2 cells. Cyclopenta(cd)pyrene and two of the four possible isomers of cyclopenta-benz(a)anthracene, benz(j)aceanthrylene, and benz(l)aceanthrylene, were metabolized by C3H10T1/2 cells to dihydrodiol metabolites including cyclopenta-ring dihydrodiols. The study examines the ability of ACE, the smallest linear-fused CP-PAH yet examined, to be metabolized, to form DNA adducts, and to induce morphological transformation in C3H10T1/2 mouse embryo fibroblasts.