| Main Title |
Tumorigenic Effect of Sodium Arsenite in Rat Kidney. |
| Author |
Shirachi, D. Y. ;
Johansen, M. G. ;
McGowan, J. P. ;
Tu, S. H. ;
|
| CORP Author |
University of the Pacific, Stockton, CA.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-R-807235; EPA/600/D-87/276; |
| Stock Number |
PB88-101605 |
| Additional Subjects |
Arsenic ;
Carcinogens ;
Malignant neoplasms ;
Kidney ;
Rats ;
Laboratory animals ;
Toxicology ;
Sodium arsenite ;
Tumor promoters ;
Tumor initiators ;
Diethylnitrosamine
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-101605 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Exposure of humans to inorganic arsenic has been associated with the development of neoplasms. This has led to the conclusion that arsenic is a carcinogen but this is without substantial experimental evidence. The major criticism of the epidemiological and experimental data is that other chemicals or conditions were often present during these exposures which complicated the interpretation of the data. Researchers have been interested in the concept that arsenic is not a complete carcinogen but would require a promoter carcinogen or is itself a promoter carcinogen. The report presents evidence that the inorganic arsenic, sodium arsenite, appears to be a promoter carcinogen in the kidney for the initiator carcinogen, diethylnitrosamine. (Copyright (c) 1983, Proc. West. Pharmacol, Soc.) |
