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Main Title Hydronephrosis in Mice Exposed to TCDD-Contaminated Breast Milk: Identification of the Peak Period of Sensitivity and Assessment of Potential Recovery.
Author Couture-Haws, L. ; Harris, M. W. ; McDonald, M. M. ; Lockhart, A. C. ; Birnbaum, L. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;North Carolina Univ. at Chapel Hill. ;Computer Sciences Corp., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/121;
Stock Number PB91-211441
Additional Subjects Tetrachlorodibenzodioxin ; Kidney diseases ; Milk ; Mammae ; Maternal-fetal exchange ; Dose-response relationships ; Newborn animals ; Mice ; Sex factors ; Food contamination ; Organ weight ; Body weight ; Liver ; Thymus gland ; Pathology ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-211441 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent inducer of hydronephrosis in mice both pre- and post-natally. To identify the critical period of susceptibility for development of TCDD-induced hydronephrosis in neonatal mice, as well as to characterize the potential for recovery from this renal lesion, dose-response and time-course studies were conducted using lactational exposure. Pregnant C57BL/6N mice were allowed natural delivery. In the dose-response phase of the investigation, mothers were administered 0, 3, 6, or 12 microgram TCDD/kg once by gavage on post natal day (pnd) 1, 4, 8, or 14, and dams and pups were sacrificed on pnd 26. In the time-course studies, dams were given a single oral dose of 0 or 9 microgram TCDD/kg on pnd 1, and mothers and litters were subsequently sacrificed on pnd 7, 13, 19, or 26. Neonatal kidneys were examined, and hydronephrotic severity was scored. The incidence and severity of hydronephrosis were significantly elevated above controls at all dose levels on pnd 26 following treatment on pnds 1 and 4, while treatment on pnd 8 or 14 was ineffective at inducing hydronephrosis.