Record Display for the EPA National Library Catalog


Main Title New Techniques for Imaging and Analyzing Lung Tissue.
Author Roggli, V. L. ; Ingram, P. ; Linton, R. W. ; Gutknecht, W. F. ; Mastin, P. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pathology. ;Research Triangle Inst., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-805460 ;EPA-R-807560; EPA/600/J-84/124;
Stock Number PB85-114080
Additional Subjects Lung ; Imaging ; Medical equipment ; Tissues(Biology) ; Pathology ; Toxicology ; Exposure ; Reprints ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB85-114080 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 24p
The recent technological revolution in the field of imaging techniques has provided pathologists and toxicologists with an expanding repertoire of analytical techniques for studying the interaction between the lung and the various exogenous materials to which it is exposed. Analytical problems requiring elemental sensitivity or specificity beyond the range of that offered by conventional scanning electron microscopy and energy dispersive X-ray analysis are particularly appropriate for the application of these newer techniques. Electron energy loss spectrometry, Auger electron spectroscopy, secondary ion mass spectrometry, and laser microprobe mass analysis each offer unique advantages in this regard, but also possess their own limitations and disadvantages. Diffraction techniques provide crystalline structural information available through no other means. Bulk chemical techniques provide useful cross-checks on the data obtained by microanalytical approaches. It is the purpose of this review to summerize themethodology of these techniques, acknowledge situations in which they have been used in addressing problems in pulmonary toxicology, and comment on the relative advantages and disadvantages of each approach.