| Main Title |
Effects of the Herbicide 2,4-Dichlorophenyl(rho)-Nitrophenyl Ether (NIT) on Serum Thyroid Hormones in Adult Female Mice. |
| Author |
Gray jr, L. E. ;
Kavlock, R. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA/600/J-83-044; |
| Stock Number |
PB84-101500 |
| Additional Subjects |
Herbicides ;
Thyroid hormones ;
Hormones ;
Females ;
Mice ;
Parenteral infusions ;
Dosage ;
Nitrogen organic compounds ;
Reprints ;
Nitrogen ;
Ether/(dichlorophenyl)-(nitrophenyl)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-101500 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
The administration of the herbicide 2,4-Dichlorophenyl-p-nitrophenyl ether (nitrofen; NIT) to adult female mice by i.p. injection at doses of 500 and 1000 mg/kg/day for 3 days, reduced serum thyroxine (T4) levels. T4 levels were reduced in the high-dosage group by 60% of the control and by 20% in the low-dose group. Serum triiodothyronine (T3) levels were relatively unaffected by NIT treatment at either dose. The animals appeared euthyoid, as body weights were unaffected even though T4 levels were reduced. Liver weights were slightly higher as a result of NIT exposure at both 500 and 1000 mg/kg/day. |
