Record Display for the EPA National Library Catalog


Main Title Effects of Inorganic Lead In vitro on Ion Exchanges and Respiratory Metabolism of Rat Kidney Cortex.
Author van Rossum, G. D. V. ; Kapoor, S. C. ; Rabinowitz, M. S. ;
CORP Author Temple Univ., Philadelphia, PA. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-68-03-2381; EPA/600/J-85/154;
Stock Number PB86-101003
Additional Subjects Lead(Metal) ; Ion exchangers ; In vitro analysis ; Rats ; Kidneys ; Tissues ; Metabolism ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB86-101003 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The effects of Pb2+ added in vitro to tissue slices, isolated tubules and isolated mitochondria of rat kidney cortex have been studied. Slices were depleted of K+ and loaded with Na+, Cl- and water by pre-incubation at 1C, and reversal of these changes was then induced by incubation under metabolically favorable conditions. The net reaccumulation of K+ was reduced by a maximum of 30% when Pb2+ was present in the medium, the maximal effect being caused by 200 micromoles Pb2+. Lead also caused a reduction of Na+ extrusion which was approximately equimolar with its effect on K+, but it did not affect the extrusion of Cl- and water. The initial rates of the net, active movements of K+ and Na+ were not altered by Pb2+, divergence from control values only being noted after 15-30 min incubation.