Record Display for the EPA National Library Catalog


Main Title Morphological and Physiological Studies of Rat Kidney Cortex Slices Undergoing Isosmotic Swelling and Its Reversal: A Possible Mechanism for Ouabain-Resistant Control of Cell Volume.
Author Russo, M. A. ; Ernst, S. A. ; Kapoor, S. C. ; van Rossum, G. D. V. ;
CORP Author Rome Univ. (Italy). Ist. di Patologia Generale. ;Michigan Univ., Ann Arbor. Medical School. ;Temple Univ., Philadelphia, PA. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-806616; EPA/600/J-85/183;
Stock Number PB86-117264
Additional Subjects Cells(Biology) ; Kidney ; Rats ; Laboratory animals ; Morphology ; Ouabain ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB86-117264 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25p
Slices of rat kidney cortex were induced to swell by preincubation at 1C in an isotonic Ringer's solution, and their capacity to reverse swelling, by net extrusion of cellular water, was studied during subsequent incubation at 25C. The recovery from swelling was prevented by the respiratory inhibitor, antimycin A. On the other hand, extrusion of water was little affected by ouabain. The extrusion of water continuing in the presence of ouabain (but not that in its absence) was significantly reduced when furosemide was added or when medium Cl- was replaced by NO-3 or I-. There was substantial variability in the morphological appearance of cells within the cortical slices.