Record Display for the EPA National Library Catalog


Main Title Further Evaluation of an In vivo Teratology Screen.
Author Kavlock, R. J. ; Short, R. D. ; Chernoff, N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Midwest Research Inst., Kansas City, MO.
Year Published 1987
Report Number EPA/600/J-87/093;
Stock Number PB88-124607
Additional Subjects Bioassay ; Mice ; Toxicity ; Chemical tests ; Carcinogens ; Mutagens ; Screening(Selection) ; Exposure ; Reprints ; Teratogens ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB88-124607 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
The in vivo teratology screening procedure described previously was further evaluated using a total of 46 chemicals in 50 different treatment regimens. Pregnant CD-1 mice were generally treated by oral gavage on days 8-12 of gestation at a dose level predicted from a preliminary range finding study to induce a slight degree of maternal toxicity. The effects on early postnatal growth and viability were compared to results generated from standard mouse teratology bioassays as reported in the literature. The procedure correctly categorized 25 of the 30 treatment regimens which were considered developmentally toxic in the mouse, as well as 9 of 11 which were considered to be nondevelopmentally toxic in the mouse. Thus, based upon the criteria used in the present study, the assay correctly classified 83% of the chemicals tested as to their effect in a standard mouse bioassay. (Copyright (c) 1987 Alan R. Liss, Inc.)