Record Display for the EPA National Library Catalog


Main Title Effect of Ozone on Human Cellular and Humoral Immunity: Characterization of T and B Lymphocytes by Rosette Formation.
Author Savino, Anthony ; Peterson, Marzda L. ; House, Dennis ; Turner, Alvis G. ; Jeffries., Harvey E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div.
Year Published 1978
Report Number EPA/600/J-78-026;
Stock Number PB-284 383
Additional Subjects Ozone ; Lymphocytes ; Blood cells ; Immunity ; Toxicology ; Exposure ; Humans ; Experimental data ; Erythrocytes ; Tables(Data) ; Males ; Reprints ; Toxic substances ; B lymphocytes ; T lymphocytes ; Rosette formation ; Humoraral immunity ; Cellular immunity ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB-284 383 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Eight healthy male subjects were exposed to 784 micrograms cu m (0.4 ppm) of ozone for 4 hours in an environmentally controlled exposure chamber. Peripheral blood samples were taken before and after air and ozone exposures and again at 72 hours and 2 weeks. These blood samples were examined for the percentages of rosette-forming T and B lymphocytes. No statistically significant depressions in T-lymphocyte rosette formation with sheep erythrocytes were found following exposure to air or ozone. The ability of B lymphocytes to form rosettes with sensitized human erythrocytes was depressed following ozone exposure. These results suggest that surface receptors and/or cell membranes of peripheral blood B lymphocytes may be temporarily altered following short-term exposure to ozone.