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Main Title Exposure of Humans to a Volatile Organic Mixture. 1. Behavioral Assessment.
Author Otto, D. A. ; Hudnell, H. K. ; House, D. E. ; Moelhave, L. ; Counts, W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div. ;Aarhus Univ. (Denmark). Inst. for Miljoe- og Arbejdsmedicin. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/195;
Stock Number PB92-189018
Additional Subjects Indoor air pollution ; Behavior ; Toxicology ; Humans ; Air quality ; Expore ; Reprints ; Volatile organic compounds ; Neurobehavioral tests ; Sick building syndrome
Library Call Number Additional Info Location Last
NTIS  PB92-189018 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Exposure to a low-level mixture of volatile organic compounds, typical of those found in new buildings, has been reported to impair neurobehavioral function in persons who have experienced sick building syndrome (SBS). Sixty-six healthy young males who had no history of chemical sensitivity were exposed for 2.75 h to a complex mixture of volatile organic compounds at 0 and 25 mg/cu m. Even though subjects reported more fatigue and more mental confusion following exposure to volatile organic compounds than to clean air, performance on 13 neurobehavioral tests was not affected. Practice or learning effects were observed if administration of many behavioral tests were repeated. Further studies are needed to clarify the relationship of exposure to volatile organic chemicals, neurobehavioral performance, and subject characteristics, e.g., age, gender, and chemical sensitivity.