The paper discusses an investigation of the combination of sorbent injection and selective non-catalytic reduction (SNCR) technologies for simultaneous SO2/NOx removal. A slurry of a urea-based solution and various Ca-based sorbents was injected at a range of temperatures and reactant/pollutant stoichiometries. Testing on a natural-gas pilot-scale reactor with doped pollutants achieved up to 80% reduction of SO2 and NOx at reactant/pollutant stoichiometric ratios of 2 and 1, respectively. SO2 emission reductions from slurry injection were enhanced compared with dry Ca(OH)2 sorbent injection methods, possibly due to sorbent fracturing to smaller, more reactive particles. Emissions from NH3 slip and N2O formation were reduced in comparison with others' published results while similar NOx reductions were obtained. The injection of the urea-based solution enhanced the SO2 removal, likely due to the formation of a (NH4)2Ca(SO4)2 (center dot) H2O compound. The results of the pilot-scale study have shown high reduction of both SO2 and NOx, suggesting the need for full-scale studies to further assess the combined sorbent/urea-based slurry injection technology.