Record Display for the EPA National Library Catalog


Main Title Monitoring of the Estrous Cycle in the Laboratory Rodent by Vaginal Lavage.
Author Cooper, R. L. ; Goldman, J. M. ; Vandenbergh., J. G. ;
CORP Author North Carolina State Univ. at Raleigh. Dept. of Zoology.;Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch.
Publisher 1992
Year Published 1992
Report Number EPA-68-02-4450; EPA/600/A-92/081;
Stock Number PB92-179068
Additional Subjects Estrus ; Vaginal smears ; Rats ; Female ; Mice ; Toxicology ; Hormones ; Light ; Circadian rhythms ; Ovulation ;
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB92-179068 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25p
Ovarian cyclicity in a number of laboratory species can be monitored easily and noninvasively by observing changes in the vaginal cytology. The chapter describes the techniques used to collect data in the laboratory rat and mouse and how to interpret the lavages as they are obtained. The relationship between the various cell types and the fluctuation in serum hormones as they exist over the cycle is described. Finally, there is a discussion of how to interpret various changes in vaginal smear patterns as they occur in response to toxicant treatment.