Record Display for the EPA National Library Catalog


Main Title Age-Related Alterations in the Stimulated Release In vitro of Catecholamines and Luteinizing Hormone-Releasing Hormone from the Male Rat Hypothalamus.
Author Goldman, J. M. ; Cooper, R. L. ; Rehnberg, G. L. ; Gabel, S. ; McElroy, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Iowa Univ., Iowa City. Coll. of Medicine.
Year Published 1987
Report Number EPA/600/J-87/128;
Stock Number PB88-144423
Additional Subjects Catecholamines ; Aging(Biology) ; Hypothalamus ; Norepinephrine ; Dopamine ; Rats ; Tissues(Biology) ; Reprints ; LH-FSH releasing hormone ; Tissue culture ; Electric stimulation
Library Call Number Additional Info Location Last
NTIS  PB88-144423 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Using an in vitro perifusion system, the present study investigated the possibility that alterations in catecholamine and luteinizing hormone-releasing hormone (LHRH) secretion from the male rat mediobasal hypothalamus are present during the period of middle-age. The results indicate that, while tissue concentrations and baseline secretion of norepinephrine, dopamine and LHRH were similar between age groups, the patterns of dopamine and LHRH release in response to a series of depolarizing stimuli was different in the older animals. After all challenges, dopamine concentrations in the perifusate declined much more sharply for the middle-aged group, a finding that may be associated with a decrease with age in the pool of transmitter available for ready release. (Copyright (c) 1987 Plenum Publishing Corporation.)