Record Display for the EPA National Library Catalog


Main Title Role of Time as a Factor in the Toxicity of Chemical Compounds in Intermittent and Continuous Exposures. Part II. Effects of Intermittent Exposure.
Author Coffin, D. L. ; Gardner, D. E. ; Sidorenko, G. I. ; Pinigan., M. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. ;Institute of General and Municipal Hygiene, Moscow (USSR).
Year Published 1977
Report Number EPA/600/J-77/105b;
Stock Number PB-278 374
Additional Subjects Nitrogen dioxide ; Sulfur dioxide ; Benzene ; Toxicology ; Laboratory animals ; Experimental data ; Respiration ; Air pollution ; Toxicity ; Exposure ; Time series analysis ; Chemical compounds ; Reprints ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB-278 374 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Because of fluctuations in levels of industrial air pollution linked to weather and other factors, a joint U.S.-Soviet research team studied differences in the effect of time in exposures of air-breathing animals to controlled varied concentrations of air pollutants. An experimental model environment was used to investigate the effects of nitrogen dioxide (NO2), sulfur dioxide (SO2), and benzene (C6H6) in the air environment of laboratory animals, with both continuous and intermittent exposures. Part II concerns the toxicities of intermittent exposures to C6H6 and NO2; three parameters were used. The toxic effects of NO2 with intermittent exposure were not reduced as was the case with C6H6. Data are presented to show that intermittent exposure to NO2 may be more toxic than continuous exposure when short-term peaks of NO2 concentrations are involved.