Record Display for the EPA National Library Catalog


Main Title Role of Time as a Factor in the Toxicity of Chemical Compounds in Intermittent and Continuous Exposures. Part I. Effects of Continuous Exposure.
Author Gardner, D. E. ; Coffin, D. L. ; Pinigin, M. A. ; Sidorenko., G. I. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. ;Institute of General and Municipal Hygiene, Moscow (USSR).
Year Published 1977
Report Number EPA/600/J-77/105a;
Stock Number PB-278 380
Additional Subjects Chemical compounds ; Toxicity ; Benzene ; Sulfur dioxide ; Nitrogen dioxide ; Mice ; Exposure ; Concentration(Composition) ; Air pollution ; Gases ; Laboratory animals ; Central nervous system ; Blood ; Physiological effects ; Toxicology ; Experimental data ; Respiration ; Time series analysis ; Bioassay ; Lethal dosage ; USSR ; Animal models ; Toxic substances ; Air pollution effects(Humans) ; Reprints
Library Call Number Additional Info Location Last
NTIS  PB-278 380 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Because of fluctuation in levels of industrial air pollution linked to weather and other factors, a joint U.S.-Soviet research team studied differences in the effect of time in exposures of air-breathing animals to controlled varied concentrations of air pollutants. An experimental model environment was used to investigate the effects of nitrogen dioxide, sulfur dioxide, and benzene in the air environment of laboratory animals, with both continuous and intermittent exposures. For intermittent exposures the investigators used amounts of toxic gases whose cumulative total equaled the total in the continuous exposures, and intercalated the intermittent exposures with periods of nonpolluted air. Part 1 of this work deals with the effects of continuous exposure to benzene on the central nervous system and blood. Toxic effects of continuous exposure to various concentrations of benzene were found in these systems. The time-effect relationships could be approximated on a log-log scale by straight lines. Similar results were obtained with sulfur dioxide. Using different parameters to measure toxicity, similar results were obtained with nitrogen dioxide, namely concentration-time relationships that when plotted on a log-log scale gave straight lines.