Record Display for the EPA National Library Catalog


Main Title Augmentation of Sulfate Ion Absorption from the Rate Lung by Heavy Metals.
Author Charles, Jeffrey M. ; Gardner, Donald E. ; Coffin, David L. ; Menzel., Daniel B. ;
CORP Author Duke Univ. Medical Center, Durham, N.C.;Health Effects Research Lab., Research Triangle Park, N.C.
Year Published 1977
Report Number EPA-68-02-2436; EPA/600/J-77/086;
Stock Number PB-278 585
Additional Subjects Absorption(Biology) ; Sulfates ; Lung ; Metals ; Air pollution ; Contaminants ; Interactions ; Respiration ; pH ; Ions ; Absorption(Biology) ; Rats ; Laboratory animals ; Reprints ; Heavy metals ; Particulates
Library Call Number Additional Info Location Last
NTIS  PB-278 585 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The effect of heavy metal cations in enhancing the absorption of sulfate ions from the airways of the rat lung was studied. The cations investigated included Cd(2+), Co(2+), Hg(2+), Ni(2+), Fe(3+), Mn(2+), and Zn(2+). The cations exhibited differing efficacies. Co(2+), Hg(2+), Cd(2+), and Ni(2+) produced maximal effect at 0.1 nmol/lung, while Fe(3+) and Zn(2+) were the least effective, reaching maximal effect at 10.0 nmol/lung. An exception was Mn(2+), which did not alter absorption. Hydrogen ion concentrations departing from physiological pH values (4.4-9.4) enhanced sulfate ion absorption. Exposure of rats to a NiCl2 aerosol of 480 micrograms of Ni/cu m for 2 hr prior to the determination of sulfate ion absorption led to a 12.0 plus or minus 2.7% enhancement of absorption. These results suggest a possible correlation between the irritant potential associated with inhalation of a specific sulfate salt and the rate at which sulfate ions are absorbed from the lung. (Copyright (c) 1977 by Academic Press, Inc.)