Record Display for the EPA National Library Catalog


Main Title Efficacy of Neurospora in Detecting Agents That Cause Aneuploidy.
Author Griffiths, A. J. F. ; Brockman, H. E. ; DeMarini, D. M. ; de Serres, F. J. ;
CORP Author Oak Ridge National Lab., TN. ;British Columbia Univ., Vancouver. ;Illinois State Univ., Normal. Dept. of Biological Sciences. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Year Published 1986
Report Number EPA-68-02-3839; EPA/600/J-86/076;
Stock Number PB86-205580
Additional Subjects Aneuploidy ; Neurospora ; Efficacy ; Reprints ; Bioindicators ; Mutagenesis
Library Call Number Additional Info Location Last
NTIS  PB86-205580 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
A committee of scientists was established by the U.S. Environmental Protection Agency to appraise the current state of aneuploidy test methodology, to compile and analyze published data on the chemical induction of aneuploidy, and to provide guidance for additional test development and validation. The committee was organized into 9 working groups, representing different eukaryotic organisms ranging from fungi to whole mammals. The Environmental Mutagen, Carcinogen, and Teratogen Information Program at Oak Ridge National Laboratory identified and provided literature to the working groups. The 9 reports were prepared by the individual working groups. The reports include: (1) descriptions of the available testing approaches and general principles to be followed for protocol development, (2) criteria for evaluating data, and (3) recommendations for future test development and basic research. The evaluated results are presented in tables. For the positive and negative calls, the lowest effective dose tested or the highest ineffective dose tested, respectively, and the range of concentrations tested are provided.