| Main Title |
Approach to the Design of Nonmutagenic Azo Dyes: Analogues of the Mutagen 4-Amino-3-Methoxyazobenzene (Chapter 4). |
| Author |
Freeman, H. S. ;
Esancy, J. F. ;
Claxton, L. D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;North Carolina State Univ. at Raleigh. Dept. of Textile Engineering, Chemistry, and Science. |
| Publisher |
1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/A-92/155; |
| Stock Number |
PB92-206556 |
| Additional Subjects |
Azo dyes ;
Mutagens ;
Chemical reactions ;
Mutagenicity tests ;
Alkoxy compounds ;
Carcinogens ;
Textile finishing ;
Nuclear magnetic resonance ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-206556 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
20p |
| Abstract |
The series of analogs of the known mutagen 4-amino-3-methoxyazobenzene has been synthesized in which the size of the alkoxy group has been varied to determine the effect of this kind of alteration on the mutagenicity of the parent dye molecule. It has been found that the dyes containing the larger alkoxy group are significantly less mutagenic than their lower homologs. In addition, the contribution of the reductive-cleavage products to the mutagenicity of the parent dye molecules was also investigated. The results of the aspect of the study indicate that mutagenicity of an azo dye, in that some of the dyes are potent mutagens but their reductive-cleavage products are either nonmutagenic or very weakly active in the standard Ames assay. |
