Record Display for the EPA National Library Catalog


Main Title Special report on ingested inorganic arsenic: skin cancer ; nutritional essentiality /
Author Levine, Tina. ; Gostomski, Frank. ; Rispin, A. ; Scott, C. S. ; Marcus, W. ; Chen, C.
Other Authors
Author Title of a Work
Levine, Tina.
Gostomski, Frank.
CORP Author United States. Environmental Protection Agency. Risk Assessment Forum.
Publisher U.S. Environmental Protection Agency,
Year Published 1987
Report Number EPA/625-3-87-013A
Stock Number PB88-174503
OCLC Number 17408723
Subjects Skin--Cancer ; Skin--Cancer--Etiology
Additional Subjects Skin--Cancer ; Skin--Cancer--Etiology ; Arsenic inorganic compounds ; Skin cancer ; Ingestion(Biology) ; Exposure ; Metabolism ; Toxicology ; Risk ; Nutrition ; Medical research ; Carcinogens
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  RA1231.A7S63 1987 Region 1 Library/Boston,MA 04/29/2016
EJED  EPA/625/3-87/013A OCSPP Chemical Library/Washington,DC 12/12/2003
ELBD ARCHIVE EPA 625-3-87-013A Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023 DISPERSAL
EMBD  EPA/625/3-87/013A NRMRL/GWERD Library/Ada,OK 02/03/1995
ESAD  EPA 625-3-87-013A Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB88-174503 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Edition SAB review draft.
Collation 1 volume (various pagings)
A technical panel of the USEPA's Risk Assessment Forum has studied three special issues regarding certain health effects, particularly skin cancer, associated with arsenic ingestion: (1) the validity of the Taiwan study and its use for dose-response assessment in the U.S. population (2) the interpretation and use of skin lesions reported as arsenic-induced skin cancers, and (3) the role of arsenic as an 'essential' nutritional requirement in the human diet. The Technical Panel also reviewed auxiliary information on genotoxicity, metabolism, and other factors that might suggest the most appropriate approach to dose-response assessment. In brief summary, the analysis shows a causal relationship between ingestion exposure to arsenic and an increased risk of skin cancer. However, there is not sufficient information to evaluate a dose-response according to any specific mechanism that one may postulate. In the absence of fully persuasive evidence for any of the possible mechanisms, a generalized multistate model that is linear at low doses was used to place an upper bound on the expected human cancer dose-response. The report summarizes the Technical Panel's review and analysis of relevant data.
Includes bibliographical references. Cover title. "Prepared for the Risk Assessment Forum, U.S. Environmental Protection Agency." "November 1987." "EPA/625-3-87-013a."