Record Display for the EPA National Library Catalog


Main Title Permeation of Mouse Skin and Silicone Rubber Membranes by Phenols: Relationship to In vitro Partitioning (Journal Version).
Author Jetzer, W. E. ; Huq, A. S. ; Ho, N. F. H. ; Flynn, G. L. ; Duraiswamy, N. ;
CORP Author Michigan Univ., Ann Arbor. Coll. of Pharmacy.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1986
Year Published 1986
Report Number EPA-R-809229; EPA/600/J-86/476;
Stock Number PB89-106876
Additional Subjects Phenols ; Membranes ; Skin ; Silicone resins ; Permeability ; Separation ; Elastomers ; Diffusion ; Solubility ; Organic solvents ; Water ; Nitrophenols ; Toxicology ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-106876 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
A discrepancy has been noted in the relationship between the relative skin permeabilities of phenols and their lipophilicities as expressed in commonly used octanol/water partition coefficients. The permeability coefficients of 4-nitrophenol and several other phenols through skin and a model lipophilic membrane made of silicone rubber were found to be independent of concentration, ruling out concentration dependent molecular aggregation as the cause of the partitioning-permeability incongruity. An unexpectedly low permation rate was observed for the diffusion of 4-nitrophenol through the synthetic, silicone rubber membrane, confirming the phenol's anomalous position in permeability relative to the octanol/water partitioning scale. However, when o/w partition coefficients for the phenolic compounds based on either n-hexane, methylene chloride, chloroform or silicone rubber as the water immiscible phase are used, permeability coefficients for the skin and the synthetic membrane followed expected permeation-partitioning dependencies.