Record Display for the EPA National Library Catalog


Main Title Dermatotoxicity : selected issues in testing for dermal toxicity, including irritation, sensitization, phototoxicity, and systemic toxicity /
Author Chaube, S. ; Falahee, K. J. ; Rose, C. S. ; Seifried, H. E. ; Taylor, T. J.
CORP Author United States. Environmental Protection Agency. Office of Pesticides and Toxic Substances.
Publisher Distributed by National Technical Information Service,
Year Published 1982
Report Number EPA 560-11-82-002; EPA-68-01-6176
Stock Number PB82-224320
OCLC Number 09750275
Subjects Toxicology--Methods ; Toxicology, Experimental
Additional Subjects Toxicology--Methods ; Toxicology, experimental ; Dermatology ; Skin diseases ; Sensitizing ; Absorption ; Mice ; Rabbits ; Guinea pigs ; Laboratory animals ; Lethal dosage ; Photosensitivity ; Contact dermatitis ; Allergic skin diseases ; Standards ; Toxic tolerances ; Phototoxicity
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA 560-11-82-002 OCSPP Chemical Library/Washington,DC 01/01/1988
ELBD ARCHIVE EPA 560-11-82-002 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB82-224320 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xiii, 155 pages : illustrations ; 28 cm
Four categories of Dermatotoxicity testing are examined: Dermal Irritation Sensitization, Systemic Toxicity, and Phototoxicity. The rabbit is most widely used for irritation; the guinea pig is also acceptable, as its sensitivity is comparable. Factors affecting dermal irritation include: the degree of occlusion, use of abrasion, the application site, and duration of exposure and observation. This review suggests a tier-like strategy utilizing pH limits and preliminary screening in the hairless mouse may be useful in evaluating irritation potential.
Contract no.: 68-01-6176. Report no.: EPA 560/11-82-002. Project officer: Charles Auer. Technical advisors: Norbert P. Page, Daljit Sawhney. Prepared by Tracor Jitco, Inc. Includes bibliographical references (pages 131-133).