Record Display for the EPA National Library CatalogRECORD NUMBER: 2 OF 2
|Main Title||Studies on the Toxicity of O,O-Dimethyl-2,2-Dichlorovinyl Phosphate (DDVP).|
|Author||Durham, William F. ; Gaines, Thomas B. ; McCauley, Robert H. ; Sedlak, Vincent A. ; Mattson., Arnold M. ;|
|CORP Author||Communicable Disease Center, Atlanta, Ga.|
|Stock Number||PB-278 093|
|Additional Subjects||Toxicology ; Pesticides ; Insecticides ; Bioassay ; Dosage ; Chlorine organic compounds ; Rats ; Laboratory animals ; Experimental data ; Lethal dosage ; Cholinesterase ; Tables(Data) ; Exposure ; Respiratory system ; Monkeys ; Chickens ; Reprints ; Toxic substances ; DDVP insecticide ; Phosphoric acid/(dichlorovinyl-ester)-(dimethyl-ester)|
The acute oral and dermal L.D.60 values of DDVP for male white rats were found to be 80 and 107 mg/kg, respectively. The corresponding values for females were 56 and 75 mg/kg. Pure DDVP was found, under the conditions studied, to be somewhat more toxic than the technical material. Feeding for 90 days on dietary levels of DDVP up to 1000 ppm caused no signs of intoxication in rats. However, dietary levels as low as 50 ppm produced definite lowering of plasma and erythrocyte cholinesterase levels. Monkeys confined for two weeks in Peet-Grady chambers which had been sprayed with 100 and 195 mg of DDVP per square foot showed depletion of both plasma and erythrocyte cholinesterase.