Record Display for the EPA National Library Catalog


Main Title Interim methods for development of inhalation reference concentrations /
Author Blackburn, K. ; Dourson, M. ; Erdreich, L. ; DeRose, C. ; Graham, J. A.
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
Publisher U.S. Environmental Protection Agency,
Year Published 1990
Report Number EPA/600/8-90/066A; ECAO-R-0204
Stock Number PB90-238890
OCLC Number 22604685
Subjects Risk assessment ; Inhalation ; Toxicity ; Chemical compounds ; Respiration ; Risk management ; Estimates ; Laboratory animals ; Reference values ; Human tolerances
Additional Subjects Toxicity ; Chemical compounds ; Respiration ; Inhalation ; Risk management ; Estimates ; Laboratory animals ; Reference values ; Human tolerances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-8-90-066A Headquarters Library/Washington,DC 12/27/2011
EJED  EPA/600/8-90/066A OCSPP Chemical Library/Washington,DC 06/13/2003
EKBD  EPA/600/8-90/066A Research Triangle Park Library/RTP, NC 11/02/1990
ELBD ARCHIVE EPA 600-8-90-066A AWBERC Library/Cincinnati,OH 03/29/2023
ESAD  EPA 600-8-90-066A Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB90-238890 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings)
An inhalation reference concentration (RfC) is an estimate of continuous inhalation exposure over a human lifetime that is unlikely to pose significant risk of adverse noncancer health effects and serves as a benchmark value for assisting in risk management decisions. Derivation of an RfC involves dose-response assessment of animal data to determine the exposure levels at which no significant increase in the frequency or severity of adverse effects between the exposed population and its appropriate control exists. The assessment requires an interspecies dose extrapolation from a no-observed-adverse-effect level (NOAEL) exposure concentration of an animal to a human equivalent NOAEL (NOAEL(HBC)). The RfC is derived from the NOAEL(HBC) by the application of generally order-of-magnitude uncertainty factors. Intermittent exposure scenarios in animals are extrapolated to chronic continuous human exposures. Relationships between external exposures and internal doses depend upon complex simultaneous and consecutive processes of absorption, distribution, metabolism, storage, detoxification, and elimination. To estimate NOAEL(HBC)s when chemical-specific physiologically-based pharmacokinetic models are not available, a dosimetric extrapolation procedure based on anatomical and physiological parameters of the exposed human and animal and the physical parameters of the toxic chemical has been developed which gives equivalent or more conservative exposure concentrations values than those that would be obtained with a PB-PK model.
"Review draft." "EPA/600/8-90/066A." "August 1990." "Office of Health and Environmental Assessment." "Environmental Criteria and Assessment Office." "Office of Research and Development." Includes bibliographical references (pages 5-1-5-15).