Record Display for the EPA National Library Catalog


Main Title Relationship between the Metabolism of Haloacetonitriles and Chloroform and Their Carcinogenic Activity.
Author Pereira, M. A. ; Daniel, F. B. ; Lin, E. L. C. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1984
Report Number EPA/600/D-84/203;
Stock Number PB84-246230
Additional Subjects Carcinogens ; Potable water ; Water treatment(Chemicals) ; Halogen organic compounds ; Chloroform ; Metabolism ; Laboratory animals ; Toxicology ; Chlorination ; In vitro analysis ; Deoxyribonucleic acids ; Public health ; Acetonitriles ; Water pollution effects(Humans) ; Acetonitrile/chloro ; Acetonitrile/dichloro ; Acetonitrile/bromo-chloro ; Acetonitrile/trichloro
Library Call Number Additional Info Location Last
NTIS  PB84-246230 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
Halogenated acetonitriles, found in chlorinated drinking water, are formed by the reaction of chlorine with algae, fulvic acid, and proteinaceous material in the source water. The metabolism of halogenated acetonitriles was investigated in relation to their possible carcinogenic activity. Chloroacetonitrile (CAN), dibromoacetonitrile (DBAN), dichloroacetonitrile (DCAN), bromochloroacetonitrile (BCAN), and trichloroacetonitrile (TCAN) were shown to bind the nucleophilic trapping agent, p-nitrobenzylpyridine, without metabolic activation and to produce strand breaks in the DNA of cultured human CCRF-CEM cells. In addition, DCAN bound DNA in vitro without metabolic activation producing an adduct to adenine, and DBAN bound rat-liver DNA following oral administration.