Record Display for the EPA National Library Catalog


Main Title Macromolecular Adduction by Trichloroacetonitrile in the Fischer 344 Rat Following Oral Gavage.
Author Lin, E. L. C. ; Reddy, T. V. ; Daniel, F. B. ;
CORP Author Environmental Monitoring Systems Lab., Cincinnati, OH.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/368;
Stock Number PB93-107134
Additional Subjects DNA adducts ; Toxicity ; Blood proteins ; Rats ; Deoxyribonucleic acids ; Dose-response relationships ; Liver ; Kidney ; Stomach ; Liquid chromatography ; Reprints ; Nitrile/trichloroaceto
Library Call Number Additional Info Location Last
NTIS  PB93-107134 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Male Fisher 344 rats were administered 1- or 2-((14)C)trichloroacetonitrile (TCAN) by oral gavage. DNA was isolated from the liver, kidneys and stomach and several protein fractions (globin, albumin and globulins) were isolated from blood. The stomach exhibited the highest level of DNA binding, followed in order by the liver and kidney. TCAN binding level was higher in DNA isolated from rats killed at 24 h than at 4 h after administration. Radioactivity associated with DNA was not incorporated into the nitrogen bases (i.e. via de novo synthesis) and a covalent binding index (micromol chemical bound/mol nucleotide phosphate per mmol/kg body wt. of chemical administered) of 30 - 120 was observed for various tissues.