Record Display for the EPA National Library Catalog


Main Title 7,12-Dimethylbenz(a)anthracene-DNA Adducts in Sprague-Dawley and Long-Evans Female Rats: The Relationship of DNA Adducts to Mammary Cancer.
Author Daniel, F. B. ; Joyce, N. J. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Year Published 1984
Report Number EPA/600/J-84/114;
Stock Number PB85-108728
Additional Subjects Breast carcinoma ; Deoxyribonucleic acid ; Rats ; Females ; Reprints ; Anthracene/dimethylbenz ; Cancer
Library Call Number Additional Info Location Last
NTIS  PB85-108728 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
7,12-dimethylbenz(a)anthracene (DMBA) is a powerful carcinogen to the mammary gland of the pubescent female Sprague-Dawley (S.D.) rat but is a much less potent inducer of mammary adenocarcinoma in the female Long-Evans (L.E.) rat of the same age. The livers of both strains are refractory to DMBA. The maximum levels of DMBA-DNA adducts formed, in both the mammary gland and liver following intraperitoneal (i.p.) administration of (3H)DMBA (21 micromoles) were significantly higher (p < 0.01) in the resistant, L.E. strain than the sensitive S.D. strain. Maximal levels of DMBA-DNA adducts were observed at 48 hr post administration of the hydrocarbon for both organs of both strains. For the S.D. animals no significant loss of adducts (relative to the 48 hr maxima) was observed from either organ at the last time point (336 hr). In contrast both organs of the L.E. strain showed some evidence of adduct removal.