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Main Title An SAB report : development of the acute reference exposure. /
Other Authors
Author Title of a Work
Daisey, Joan M.
Pfitzer, Emil A.
Utell, Mark J.
CORP Author Environmental Protection Agency, Washington, DC. Science Advisory Board.
Publisher United States Environmental Protection Agency, Science Advisory Board,
Year Published 1998
Report Number EPA-SAB-EHC-98-006; EPA-SAB-EHC-99-005
Stock Number PB99-124398
OCLC Number 41113965
Additional Subjects Acute exposure ; Inhalation ; Hazardous materials ; Dose-response relationships ; Chemical compounds ; Health hazards ; Toxicity ; Exposure ; Human populations ; Dose rates ; Benchmarks ; Regression analysis ; Categorical regression ; NOAEL(No-Observable- Adverse-Effect)
Internet Access
Description Access URL$File/ehc9905.pdf
Library Call Number Additional Info Location Last
EHAD  EPA SAB-EHC-98-006 Region 1 Library/Boston,MA 01/04/2016
EJAD  EPA SAB/EHC-99-005 Region 3 Library/Philadelphia, PA 08/27/1999
EJBD  EPA-SAB-EHC-99-005 Headquarters Library/Washington,DC 07/07/2016
ELBD ARCHIVE EPA-SAB-EHC-98-005 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA SAB-EHC-99-005 AWBERC Library/Cincinnati,OH 09/08/2000
ESAD  SAB-EHC-99-005 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB99-124398 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 24 pages ; 28 cm
The Environmental Health Committee (EHC) reviewed the EPA's methodology document, 'Methods for Exposure-Response Analysis for Acute Inhalation Exposure to Chemicals, Development of the Acute Reference Exposure'. the EHC commends the Agency for developing methodology to derive Acute Reference Exposures (ARE), a chemical-specific acute exposure (with an uncertainty spanning an order of magnitude) that is not likely to cause adverse effects in a human population. Overall, approaches for the NOAEL and the benchmark concentration and for duration extrapolation were found to be clear and appropriate. However, the EHC does not support the use of the categorical regression (CatReg) approach for developing an ARE based on the lack of biological-plausibility for the methodology, the lack of justification for the scaling factor to accommodate within-group correlations and group size and the unrealiability of the types of confidence limits used.
Cover title. "EPA-SAB-EHC-99-005." "November 23, 1998." Includes bibliographical references.