| Main Title |
Feasibility of applying field ionization mass spectroscopy to pesticide research / |
| Author |
Dyer, R. L. ;
Heck, H. d'A. ;
Scott, A. C. ;
Anbar., M.
|
| Other Authors |
|
| CORP Author |
Stanford Research Inst., Menlo Park, Calif.;Health Effects Research Lab., Research Triangle Park, N.C. |
| Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory, |
| Year Published |
1976 |
| Report Number |
EPA-600/1-76-037; EPA-68-02-1799 |
| Stock Number |
PB 262 241 |
| OCLC Number |
42786668 |
| Subjects |
Pesticides--Research ;
Mass spectrometry
|
| Additional Subjects |
Pesticides ;
Chemical analysis ;
Mass spectroscopy ;
Toluidines ;
Nitro compounds ;
Synthesis(Chemistry) ;
Tissues(Biology) ;
Isotopic labeling ;
Insecticides ;
Herbicides ;
Concentration(Composition) ;
Gas chromatography ;
Error analysis ;
Toxicology ;
Bioassay ;
Thin layer chromatography ;
Feasibility ;
Extraction ;
Biological extracts ;
Rats ;
Parathion ;
Trifluralin ;
Methyl parathion ;
Field ionization mass spectroscopy ;
Toluidine/dinitro-N-N-dipropyl-triflucro ;
Pesticide residues
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD ARCHIVE |
EPA 600-1-76-037 |
|
Headquarters Library/Washington,DC |
08/12/2013 |
| EJBD |
EPA 600-1-76-037 |
|
Headquarters Library/Washington,DC |
04/08/2014 |
| EKBD |
EPA-600/1-76-037 |
|
Research Triangle Park Library/RTP, NC |
06/06/2003 |
| NTIS |
PB-262 241 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
ix, 77 p. ; 28 cm. |
| Abstract |
An isotope dilution methodology was developed for analysis of an insecticide, parathion, and a herbicide, trifluralin, isolated from rat tissues and excreta. Sample cleanup was facilitated by use of high-pressure gel permeation chromatography in conjunction with thin layer chromatography and reversed-phase high pressure liquid chromatography. Isotope ratio measurements were performed using multilabeled stable isotopic carriers and nonfragmenting field ionization mass spectrometry. Parathion and trifluralin were administered intraperitoneally and/or orally at the sub-mg/kg level, and the unchanged materials assayed in tissues and excreta at the ppb level. The technique was also applied to the determination of parathion and methyl parathion concentrations in aerosols. The biological implications of the results of the animal experiments are discussed. |
| Notes |
"EPA-600/1-76-037." |
