Record Display for the EPA National Library Catalog


Main Title Feasibility of applying field ionization mass spectroscopy to pesticide research /
Author Dyer, R. L. ; Heck, H. d'A. ; Scott, A. C. ; Anbar., M.
Other Authors
Author Title of a Work
Heck, Henry d'A.
CORP Author Stanford Research Inst., Menlo Park, Calif.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1976
Report Number EPA-600/1-76-037; EPA-68-02-1799
Stock Number PB 262 241
OCLC Number 42786668
Subjects Pesticides--Research ; Mass spectrometry
Additional Subjects Pesticides ; Chemical analysis ; Mass spectroscopy ; Toluidines ; Nitro compounds ; Synthesis(Chemistry) ; Tissues(Biology) ; Isotopic labeling ; Insecticides ; Herbicides ; Concentration(Composition) ; Gas chromatography ; Error analysis ; Toxicology ; Bioassay ; Thin layer chromatography ; Feasibility ; Extraction ; Biological extracts ; Rats ; Parathion ; Trifluralin ; Methyl parathion ; Field ionization mass spectroscopy ; Toluidine/dinitro-N-N-dipropyl-triflucro ; Pesticide residues
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-76-037 Headquarters Library/Washington,DC 04/08/2014
EKBD  EPA-600/1-76-037 Research Triangle Park Library/RTP, NC 06/06/2003
ELBD ARCHIVE EPA 600-1-76-037 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB-262 241 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation ix, 77 p. ; 28 cm.
An isotope dilution methodology was developed for analysis of an insecticide, parathion, and a herbicide, trifluralin, isolated from rat tissues and excreta. Sample cleanup was facilitated by use of high-pressure gel permeation chromatography in conjunction with thin layer chromatography and reversed-phase high pressure liquid chromatography. Isotope ratio measurements were performed using multilabeled stable isotopic carriers and nonfragmenting field ionization mass spectrometry. Parathion and trifluralin were administered intraperitoneally and/or orally at the sub-mg/kg level, and the unchanged materials assayed in tissues and excreta at the ppb level. The technique was also applied to the determination of parathion and methyl parathion concentrations in aerosols. The biological implications of the results of the animal experiments are discussed.