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Main Title Effects of 4-ter-Octylphenol on Xenopus tropicalis in a Long Term Exposure.
Author K. L. Porter ; A. W. Olmstead ; D. M. Kumsher ; W. E. Dennis ; R. Sprando
CORP Author Army Center for Environmental Health Research, Fort Detrick, MD.
Year Published 2011
Report Number EPA-IAG-DW-21-92262901-0
Stock Number ADA553581
Additional Subjects Estrogens ; Exposure(Physiology) ; Frogs ; Receptor sites(Physiology) ; Amphibians ; Control ; Induction systems ; Ratios ; Sampling ; Sex ; Sex glands ; Time intervals ; Water supplies ; Xenopus tropicalis ; Octylphenol estrogenic vitellogenin ; Oviducts ; Endocrine disruptor
Library Call Number Additional Info Location Last
NTIS  ADA553581 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 47p
We exposed Xenopus tropicalis to 1, 3.3, 11 and 36 ug/L octylphenol from Neiuwkoop-Faber (NF) state 46 tadpoles through adulthood in a flow-through water system. At NF stage 5, a random subsample of froglets was collected and assessed, while the remaining frogs were exposed through 31 weeks. Significant induction of vitellogenin was observed in the high treatment at the larval subsampling for both sexes, but not at the final sampling for either sex. No significant deviation from control for sex ratio was observed for either sampling period, suggesting minimal to no effect on gonad differentiation. Oviduct development was observed in males exposed to octylphenol. These results indicate that octylphenol exposure can induce vitellogenin in immature froglets and the development of oviducts in male adult frogs. The lack of effect observed on the developing gonads suggests that in amphibians, secondary sex characteristics are more susceptible to estrogenic compounds than developing gonads.