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Main Title Pyrethroid Insecticides and the gamma-Aminobutyric Acid (Alpha) Receptor Complex: Motor Activity and the Acoustic Startle Response in the Rat (Journal Version).
Author Crofton, K. M. ; Reiter, L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/405;
Stock Number PB89-105662
Additional Subjects Pyrethrins ; Startle reaction ; Motor activity ; GABA receptors ; Insecticides ; Laboratory animals ; Central nervous system ; Drug interactions ; Picrotoxin ; Muscimol ; Chlordiazepoxide ; Reprints ; Cismethrin ; Deltamethrin
Library Call Number Additional Info Location Last
NTIS  PB89-105662 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Two behavioral tests, locomotor activity and the acoustic startle response (ASR), were utilized to test for dose-addition of cismethrin, a Type I, or deltamethrin, a Type II pyrethroid, with compounds active to the gamma-aminobutryic acid (GABA) receptor complex (picrotoxin, muscimol, and chlordiazepoxide). All compounds produced dosage-dependent decreases in locomotor activity. Muscimol and picrotoxin decreased ASR amplitude, increased ASR latency and decreased ASR sensitization. Results from the interaction studies indicate dose-addition of picrotoxin and deltamethrin on locomotor activity and the ASR. These data produce further evidence for the differences between the in vivo effects of Type I and Type II pyrethroids, and suggest that the in vivo effects of the Type II pyrethroid deltamethrin may be due in part to interaction with the picrotoxinin binding site of the GABA receptor-ionophore complex. In addition, these results are consistent with reported differential effects of the two classes of pyrethroids on the GABA receptor complex. (Copyright (c) 1987 by the American Society for Pharmacology and Experimental Therapeutics.)