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Main Title Immune Alterations in Rats Following Subacute Exposure to Tributyltin Oxide.
Author Smialowicz, R. J. ; Riddle, M. M. ; Rogers, R. R. ; Luebke, R. W. ; Copeland, C. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;NSI Technology Services Corp., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/331;
Stock Number PB91-149773
Additional Subjects Toxicology ; Immune system ; Pesticides ; Rats ; Dose-response relationships ; Cyclophosphamide ; Lipopolysaccharides ; Erythrocytes ; Plaque assay ; T lymphocytes ; Suppressor cells ; Kinetics ; Delayed hypersensitivity ; Reprints ; Tributyltin oxide
Library Call Number Additional Info Location Last
NTIS  PB91-149773 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Adult male Fischer 344 rats were dosed by oral gavage with bis(tri-n-butyltin) oxide (TBTO) in peanut oil on ten consecutive days, at dosages ranging from 1.25 to 15 mg/kg/day. Other groups of rats were dosed daily for 10 days by oral gavage with cyclophosphamide (CY) at dosages ranging from .75 to 6 mg/kg/day. These rats served as positive controls for the immune assays employed. The immune function parameters examined included the following: delayed-type hypersensitivity (DTH) and antibody responses to bovine serum albumin (BSA), primary antibody responses to sheep red blood cells (SRBC) and trinitrophenyl lipopolysaccharide (TNP-LPA), and enumeration of splenic lymphocyte populations. The DTH and antibody responses to BSA were not effected by TBTO exposure; however these responses were suppressed in rats dosed with CY at 6 mg/kg/day. The plaque forming cell (PFC) response to the T cell-dependent antigen SRBC was enhanced in rats dosed with TBTO at from 5 to 15 mg/kg/day. On the other hand, the PFC response to the T cell-independent antigen TNP-LPS was unaffected by TBTO exposure. Rats dosedwith CY had suppressed PFC responses to SRBC and TNP-LPS at dosages of 3 and 6 mg/kg/day, respectively. (Copyright (c) 1990 Elsevier Scientific Publishers Ireland Ltd.)