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Main Title Toxicokinetics of Fenvalerate in Rainbow Trout ('Salmo gairdneri') (Journal Version).
Author Bradbury, S. P. ; Coats, J. R. ; McKim, J. M. ;
CORP Author Environmental Research Lab.-Duluth, MN. ;Iowa State Univ., Ames. Dept. of Entomology.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/485;
Stock Number PB89-104418
Additional Subjects Toxic substances ; Insecticides ; Salmo gairdneri ; Trout ; Toxicity ; Gills ; Pharmacokinetics ; Tissue distribution ; Metabolism ; Biotransformation ; Excretion ; Degration ; Toxicology ; Chlorine organic compounds ; Aquatic organisms ; Reprints ; Fenvalerate ; Benzene acetic acid/cyano(phenoxyphenyl)methyl-chloro-(methylethyl)
Library Call Number Additional Info Location Last
NTIS  PB89-104418 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
An in vivo rainbow trout (Salmo gairdneri) preparation was used to evaluate the gill uptake and toxicokinetics of (3H)fenvalerate ((R,S)-alpha-cyano-3-phenoxybenzyl (R,S)-2-(4-chlorophenyl)-3-methylbutyrate), a synthetic pyrethroid insecticide. Fish were exposed to technical-grade fenvalerate (0.28 or 23 ng/L) or an emulsifiable-concentrate formulation (16 ng/L) for 36 to 48 h. No significant effects of emulsifiers or fenvalerate concentration on uptake were observed. The overall mean gill uptake efficiency was determined to be 28.6. Following 8- to 48-h depuration periods, carcass and bile contained 80 to 90 percent and 10 to 20 percent of the gill-absorbed doses, respectively. Analysis of biliary metabolites indicated that the glucuronide of 4'-HO-fenvalerate was the only significant degradation product. Results from the present study suggest that efficient gill uptake does not explain the extreme sensitivity of fish to fenvalerate. Rather, a low rate of biotransformation and excretion may play a significant role in the susceptibility of rainbow trout to the synthetic pyrethroid insecticides. (Copyright (c) 1986 SETAC.)