Record Display for the EPA National Library Catalog


Main Title Assessing the Use of Known Mutagens to Calibrate the 'Salmonella typhimurium' Mutagenicity Assay. 1. Without Exogenous Activation.
Author Claxton, L. D. ; Houk, V. S. ; Monteith, L. G. ; Myers, L. E. ; Hughes, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Research Triangle Inst., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/264;
Stock Number PB92-113257
Additional Subjects Salmonella typhimurium ; Mutagenicity tests ; Mutagens ; Metabolic activation ; Dose-response relationships ; Tables(Data) ; Data bases ; Rats ; Liver ; Comparison ; Reprints ; Standard reference materials
Library Call Number Additional Info Location Last
NTIS  PB92-113257 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
There has been an increasing need in genetic toxicology to progress from strictly qualitative tests to more quantitative tests. This, in turn, has increased the need to develop better quality assurance and comparative bioassay methods. In the paper, two laboratories tested 10 Salmonella mutagens in order to determine the usefulness of selected chemicals as potential reference materials to calibrate the Salmonella assay. If variance within a bioassay is sufficiently low and the rankings of the compounds are of acceptable consistency, the chemicals later could be evaluated for use as standard control compounds, as audit materials, and as standard reference materials for comparative bioassay efforts. The results demonstrated that the chosen chemicals (with the possible exception of dimethylcarbamylchloride) provide such consistent results in the Salmonella mutagenicity bioassay that they can be used for semi-quantitative calibration and as possible bioassay controls, special audit chemicals, and potentially as reference standards in comparative bioassay efforts. (Copyright (c) 1991 Elsevier Science Publishers B.V.)