Record Display for the EPA National Library Catalog


Main Title Evaluation of Genotoxic Effects in Human Populations.
Author Waters, M. D. ; Allen, J. W. ; Claxton, L. D. ; Garrett, N. E. ; Huang, S. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/D-84-013;
Stock Number PB84-128982
Additional Subjects Toxicology ; Genetics ; Humans ; Evaluation ; Chromosomes ; Genes ; Mutations ; Exposure ; Dosimetry ; Deoxyribonucleic acids ; Genotoxicity
Library Call Number Additional Info Location Last
NTIS  PB84-128982 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 67p
There are demonstrable associations in experimental animals between DNA damage in somatic cells and the development of cancer, and between DNA damage in germ cells and the incidence of genetic disease in offspring. Thus, there is substantial evidence of the need to detect and to quantitate chemically-induced genetic damage in humans in order to assess the potential for cancer and genetic disease. Current methods for estimating human risk of cancer have been based on knowledge of human exposure and epidemiological data. An alternative approach would base such estimates of risk on knowledge of exposure and of damage to the DNA of human cells and tissues. The principal difficulty in performing such assessments lies in the uncertainty of translating information from tests for genetic damage in human cells and tissues into reliable estimates of risk for cancer or genetic disease. This poster concerns: (1) the development of mammalian cell methods that may be used ultimately to evaluate genotoxic effects in humans and (2) our initial attempts to implement a 'parallelogram' approach whereby such methods can be used, collectively, to relate quantitative information on genetic damage to quantitative estimates of risk for cancer or genetic disease.