Record Display for the EPA National Library Catalog


Main Title Evaluation and estimation of potential carcinogenic risks of polynuclear aromatic hydrocarbons (PAH)
Author Chu, Margaret M. L. ; Chen, C. W.
Other Authors
Author Title of a Work
Chen, Chao W.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Office of Research and Development,
Year Published 1985
Report Number EPA 600/D-89/049 ; OHEA-C-147
Stock Number PB89-221329
OCLC Number 37908525
Subjects Polycyclic aromatic hydrocarbons
Additional Subjects Aromatic polycyclic hydrocarbons ; Public health ; Carcinogens ; Exposure ; Bioassays ; Epidemiology ; Mathematical models ; Hazardous materials ; Dosage ; Assessments ; Laboratory animals ; In vivo analysis ; Risk assessment ; Occupational safety and health ; Environmental monitoring
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
ESAD  EPA 600-D-89-049 Region 10 Library/Seattle,WA 11/07/1997
NTIS  PB89-221329 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
The evaluation and estimation of the potential risk of human exposures to a hazardous substance requires the analysis of all relevant data to answer two questions: does the agent cause the effect and what is the relationship between dose (exposure) and incidence of the effect in humans. For polynuclear aromatic hydrocarbons (PAH), carcinogenicity is the effect of concern. Three types of evidence can be used to evaluate the likelihood that a PAH is carcinogenic to humans. They are epidemiologic evidence, experimental evidence derived from long-term animal bioassays, supportive or suggestive evidence from short-term tests, metabolism, pharmacokinetics and structure-activity correlations. Mathematical modeling can be used to estimate the potential human risks. The approaches and the problems associated with these approaches for estimating cancer risk to humans are addressed with special emphasis on problems related to PAH.
"Prepared for presentation at the 1984 Chemical Congress of Pacific Basin Societies."--Cover. References: p. 26-29.