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Main Title Armitage-Doll Two-Stage Model: Implications and Extension.
Author Chen, C. W. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/293 ;OHEA-C-462;
Stock Number PB93-222842
Additional Subjects Carcinogens ; Risk assessment ; Mathematical models ; Hazards ; Cancer ; Exposure ; Reprints ; MVK model ; Two-stage models ; ADT model
Library Call Number Additional Info Location Last
NTIS  PB93-222842 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The objective of the paper is twofold: (1) to provide insight on the simplified MVK model of carcinogenesis by revealing the relationship between the Armitage-Doll two-stage model (ADT model) and the simplified MVK model; and (2) to extend the ADT model to one with time-varying (piece-wise constant) parameters. It is shown that the simplified MVK model is a special case of the Armitage-Doll two-stage model , and many applications of the simplified MVK model involving intermittent exposures or exposures to different compounds in different time periods can be derived easily from the ADT model with piece-wise constant parameters. The limitations of the ADT model are discussed. (Copyright (c) 1993 Society for Risk Analysis.)