Record Display for the EPA National Library Catalog


Main Title Volatile organic compounds in whole blood - determination by heated dynamic headspace purge and trap isotope dilution GC/MS /
Author Cramer, P. H. ; Boggess, K. E. ; Hosenfeld, J. M.
Other Authors
Author Title of a Work
Cramer, Paul H.
Boggess, Kathy E.
Hosenfeld, John M.
CORP Author Midwest Research Inst., Kansas City, MO.;Environmental Protection Agency, Washington, DC. Office of Pesticides and Toxic Substances.
Publisher Office of Pesticide and Toxic Substances,
Year Published 1987
Report Number EPA/560/5-87/008; EPA-68-02-4252; Proj.; MRI-8822-A(01)
Stock Number PB88-102918
OCLC Number 18799741
Additional Subjects Blood analysis ; Toxicology ; Gas chromatography ; Mass spectroscopy ; Isotopes ; Labeled substances ; Dilution ; Purging ; Traps ; Volatile organic compounds ; Toxic substances
Internet Access
Description Access URL;&rank=4&template=epa
Library Call Number Additional Info Location Last
EHAM  EPA/560/5-87/008 Region 1 Library/Boston,MA 05/25/2016
EJED NPCD EPA 560/5-87-008 OCSPP Chemical Library/Washington,DC 08/10/2001
EJED  EPA 560/5-87-008 OCSPP Chemical Library/Washington,DC 08/10/2001
ELBD ARCHIVE EPA 560-5-87-008 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023 DISPERSAL
EMBD  PB88-102918 MF NRMRL/GWERD Library/Ada,OK 06/26/1992
ERAD  EPA 560/5-87/008 Region 9 Library/San Francisco,CA 11/27/1992
ESAD  EPA 560-5-87-008 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB88-102918 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 32 pages
The method described was developed for the determination of a selected list of 30 organic compounds in whole human blood. The method is a heated dynamic head-space purge and trap gas chromatographic method using mass spectrometry in the limited mass scan mode. A whole blood sample is diluted with organic free water and the mixture fortified with isotopically labeled compounds. The mixture is subsequently heated to 50 deg C while stirred and the volatile components are purged from the mixture and collected on an adsorbent trap. The volatile compounds are thermally desorbed from the trap onto a wide-bore fused silica capillary column. Detection of the compounds is accomplished using mass spectrometry in the limited mass scan mode where only selected ions are scanned. Quantitation of the analytes is accomplished by using the specific ion responses from standards of the analytes and their corresponding labeled analogs or internal standards.
"July 24, 1987."