Record Display for the EPA National Library Catalog


Main Title Protein adduct forming chemicals for exposure monitoring : chemicals selected for further study /
Author Schnell, Frank C. ; Chiang, T. C.
Other Authors
Author Title of a Work
Chiang, Tom C.
Nauman, Charles H.
CORP Author Lockheed Engineering and Sciences Co., Inc., Las Vegas, NV.;Environmental Monitoring Systems Lab., Las Vegas, NV.
Publisher U.S. Environmental Protection Agency, Environmental Monitoring Systems Laboratory ; Available from the National Technical Information Service,
Year Published 1989
Report Number EPA/600/4-89/035; 68-03-3249; EPC-68-03-3249
Stock Number PB90-151762
OCLC Number 36679277
Subjects Chemicals--Testing ; Toxicity testing--United States
Additional Subjects Proteins ; Carcinogens ; Toxicity ; Hydrolysis ; Tables(Data) ; In vitro analysis ; In vivo analysis ; Hemoglobins ; Aromatic compounds ; Detoxification ; Diagrams ; Adducts ; Metabolic activation ; Dose-response relationships ; Environmental monitoring ; Environmental exposure pathways
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA/600/4-89/035 OCSPP Chemical Library/Washington,DC 01/13/2001
ELBD  EPA 600-4-89-035 AWBERC Library/Cincinnati,OH 05/08/1998
NTIS  PB90-151762 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vii, 169 p. : ill. ; 28 cm.
The present report is an in-depth characterization of twenty-two chemicals and the protein (primarily hemoglobin) adducts that are formed following exposure to these compounds. These chemicals were recommended for further study in a recent internal report which described the state of the science with regard to chemicals and adducts potentially of interest for exposure monitoring. The twenty-two compounds which are evaluated are ranked and placed in one of the following categories: (1) Simple alkylating and arylating agents that form N-terminal valine adducts, (2) Aromatic amines that form hydrolyzable cysteine adducts, (3) Chemicals that form hydrolyzable, but less well-characterized adducts, (4) Chemicals that form characterized, but nonhydrolyzable adducts, and (5) Chemicals that form poorly characterized adducts.
"October 1989." "EPA/600/4-89/035." "Contract no. 68-03-3249." "Work assignment manager, Charles H. Nauman." Includes bibliographical references.