Record Display for the EPA National Library Catalog


Main Title Predictive Assay for Rodent Carcinogenicity Using In vivo Biochemical Parameters: Operational Characteristics and Complementarity.
Author Kitchin, K. T. ; Brown, J. L. ; Kulkarni, A. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;University of South Florida, Tampa. Coll. of Public Health.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/259;
Stock Number PB92-206390
Additional Subjects Carcinogenicity tests ; Carcinogens ; Biochemistry ; Toxicology ; Risk assessment ; In vivo analysis ; Species specificity ; Mutagenicity tests ; Predictive value of tests ; Rats ; Enzymes ; Mutations ; Tables(Data) ; Graphs(Charts) ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-206390 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 22p
Linear models of risk assessment may be appropriate for chemicals that are initiators of carcinogenesis while threshold models of risk assessment have been proposed for promoters. The proper risk assessment model for the regulation of promoters of carcinogenesis remains an active area of research and controversy. Cancer is a multistage process (e.g. initiation, promotion and progression). These three stages of the oncogenic process have different biological characteristics. Studies to determine which chemicals effect which stages and to what degree are needed for risk assessment. The in vivo biochemical system described in the report can be performed in a species specific and organ specific manner. In the study 111 chemicals were administered to rats, and the operational characteristics for predicting rodent carcinogenicity determined. The complementarity to short-term mutagencity tests was also demonstrated.