Record Display for the EPA National Library Catalog


Main Title Brain Cholinesterase Activity of Bobwhite Acutely Exposed to Chlorpyrifos.
Author Cairns, M. A. ; Maguire, C. C. ; Williams, B. A. ; Bennett., J. K. ;
CORP Author Corvallis Environmental Research Lab., OR. ;NSI Technology Services Corp., Corvallis, OR.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/108;
Stock Number PB91-207019
Additional Subjects Brain chemistry ; Dursban ; Cholinesterase ; Birds ; Organophosphate insecticides ; Dose-response relationships ; Toxicity ; Statistical analysis ; Reprints ; Northern bobwhite ; Chlorpyrifos ; Colinus virginianus
Library Call Number Additional Info Location Last
NTIS  PB91-207019 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Northern bobwhite, Colinus virginianus, were orally dosed with the organophosphorus insecticide chlorpyrifos to examine effects on brain cholinesterase (AChE) activity. Two-week-old quail were acutely exposed and euthanized at selected times following gavage-dosing, ranging from 1 to 120 h later. The AChE activity was determined in treated birds and compared to concurrently tested control (corn oil) birds. It was found that a lag time of 2 to 4 h following dose exposure was necessary to detect significant AChE depression caused by chlorpyrifos. The lowest dose that produced ChE to detect significant ChE depression in these tests was between approximately 30 and 50 mg chlorpyrifos/kg body weight, with some mortality occurring at the high end of that range. Depression typically persisted for at least 24 h.