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Main Title Mutagenicity and carcinogenicity assessment of 1,3-butadiene.
Author Bayard, S. ; Beliles, R. P. ; Chiu, A. ; Gibb, H. J. ; Sadler, B.
CORP Author United States. Environmental Protection Agency. Office of Health and Environmental Assessment.
Publisher Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1985
Report Number EPA-600/8-85-004 F; EPA-600/8-85-004 A
Stock Number PB86-125507; PB85-181097
OCLC Number 12960165
Subjects Butadiene--Toxicology. ; Carcinogens. ; Mutagens. ; Environmental health.
Additional Subjects Butadiene--Toxicology ; Carcinogens ; Mutagens ; Environmental health ; Environmental surveys ; Industrial medicine ; Rubber industry ; Laboratory animals ; Exposure ; Toxicity ; Inspection ; Hazardous materials ; Air pollution ; Risk ; Butadienes ; Chemical analysis ; Styrene butadiene resin ; Ventilation ; Assessments ; Dosage ; Bacteria ; In vivo analysis ; Toxic substances ; Occupational safety and health ; Indoor air pollution ; Salmonella typhimurium ; Styrene butadiene resins
Internet Access
Description Access URL
EPA 600/8-85-004F
EPA 600/8-85-004A
Library Call Number Additional Info Location Last
EHAM  RA1247.B8 EPA-600 8-85 -004F Region 1 Library/Boston,MA 04/29/2016
EJBD  EPA-600/8-85-004A Headquarters Library/Washington,DC 02/28/2007
EJBD ARCHIVE EPA 600-8-85-004F Headquarters Library/Washington,DC 03/10/2016
EJED  EPA 600/8-85-004A OCSPP Chemical Library/Washington,DC 06/14/2002
EKBD  EPA-600/8-85-004A Research Triangle Park Library/RTP, NC 04/16/2004
EKBD  EPA-600/8-85-004F c.2 Research Triangle Park Library/RTP, NC 08/23/2016
EKBD  EPA-600/8-85-004F c.1 Research Triangle Park Library/RTP, NC 08/23/2016
ERAD  EPA 600/8-85-004F Region 9 Library/San Francisco,CA 02/26/2013
ESAD  EPA 600-8-85-004A Region 10 Library/Seattle,WA 03/23/2010
ESAD  EPA 600-8-85-004 F Region 10 Library/Seattle,WA 01/02/1998
NTIS  PB85-181097 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
NTIS  PB86-125507 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) : illustrations ; 28 cm
1,3-Butadiene has been shown to be an indirect mutage in bacteria. Two of its potential metabolites, 3,4- epoxybutene and diepoxybutane, are genotoxic in prokaryote as well as eukaryote test systems. Exposure of rodents to 1,3-butadiene results in ovarian tumors in mice and testicular tumors in rats, which offers suggestive evidence that 1,3-butadiene (or a motabolite of 1,3-butadiene) may reach the germ cells. There is also evidence that the dimer of 1,3-butadiene, 4-vinyl-1-cyclohexene, causes ovarian tumors in mice. The total body of evidence, including metabolism, mutagenicity and carcinogenicity data, suggests that 1,3-butadiene may present a genetic risk to humans. However, mutagenicity studies in mammalian test systems should be conducted to further characterize the mutagenic potential of 1,3-butadiene. On the basis of sufficient evidence from studies in two species of rodents, and inadequate epidemiologic data, 1,3-butadiene can be classified, according to EPA's Proposed Guidelines for Carcinogen Risk Assessment, as a 'probable' human carcinogen, Group B2. Using the classification scheme of the International Agency for Research on Cancer, 1,3-butadiene would be classified as a 'probable' human carcinogen, Group 2B.
"Final report." Distributed to depository libraries in microfiche. "September 1985." Includes bibliographical references (pages 7-1-7-7). "EPA-600/8-85-004F."