Record Display for the EPA National Library Catalog


Main Title Morphometric Characteristics of Cells in the Alveolar Region of Mammalian Lungs.
Author Crapo, J. D. ; Young, S. L. ; Fram, E. K. ; Pinkerton, K. E. ; Barry, B. E. ;
CORP Author Duke Univ. Medical Center, Durham, NC. ;Veterans Administration Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83/279;
Stock Number PB85-176873
Additional Subjects Cells(Biology) ; Lungs ; Mammals ; Morphology ; Characteristics ; Humans ; Dogs ; Baboons ; Rats ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB85-176873 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Morphometric procedures have been used to study the characteristics of cells in the alveolar region of the lungs of rats, dogs, baboons, and humans. Compared with the other species, human lungs were found to contain greater numbers of macrophages and to have larger alveolar type II, endothelial, and interstitial cells. The thickness of the interstitium and the pulmonary capillary endothelium were also significantly greater in the human lungs. These differences in human lung anatomy may be due to increased exposure to airborne pollutants and to tobacco smoke. Despite the above differences and the fact that there are larger variations in size and functional characteristics of the lungs of these mammals, an overall striking similarity in characteristics of individual lung cells was found. The distribution of cells in alveolar tissue was remarkably constant between species as was the average volume and surface area of most cell types.