Record Display for the EPA National Library Catalog


Main Title Assessing the Neurotoxic Potential of Chemicals: A Multidisciplinary Approach.
Author Becking, G. C. ; Boyes, W. K. ; Damstra, T. ; MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/368;
Stock Number PB93-228948
Additional Subjects Nervous system ; Toxicity ; Chemical compounds ; Risk assessment ; Exposure ; Biological effects ; Health hazards ; Public health ; Testing ; Screening ; Standards ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-228948 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Since 1981, the development of methodology to assess the neurotoxic potential of chemicals has been a high priority within the International Programme on Chemical Safety (IPCS). Following the completion of an in-depth review of the scientific principles and methods for the assessment of neurotoxicity associated with chemical exposures, IPCS started to develop a multidisciplinary and comprehensive approach for neurotoxicity testing of chemicals. In view of the complexity of the nervous system and the variety of effects caused by chemicals, no single test or approach will be appropriate. Initially, IPCS evaluated neurobehavioral tests as well as in vitro procedures as screening tests, and an international collaborative study of neurobehavioral tests appropriate for screening chemicals for neurotoxicity is now in progress. Possible integration of higher level neurobehavioral tests with neurophysiological, biochemical, and pathological procedures in future testing strategies are discussed. (Copyright (c) 1993 Academic Press, Inc.).