Record Display for the EPA National Library Catalog


Main Title Sensory Evoked Potentials: Measures of Neurotoxicity.
Author Boyes, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher 1992
Year Published 1992
Report Number EPA/600/A-92/065;
Stock Number PB92-164805
Additional Subjects Somatosensory evoked potentials ; Toxicology ; Nervous system ; Senses ; Humans ; Laboratory animals ; CNS disorders ; Species specificity ; Toxic substances ;
Library Call Number Additional Info Location Last
NTIS  PB92-164805 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 57p
There is a need for tests of sensory function to be incorporated in laboratory animal toxicity testing. It is clear that sensory dysfunction may frequently occur, but go undetected, in standard animal toxicological testing protocols. Sensory evoked potential technology can be employed to address this need, can provide information regarding perceptual deficits arising from toxic insults, and can yield information regarding possible mechanisms of action. In addition, sensory evoked potential changes in laboratory animals can be predictive of sensory changes in humans. Further research is needed to better define the neural substrates of evoked potentials and their perceptual correlates so that the implications of evoked potential changes for the cellular targets, mechanisms of actions, and perceptual correlates of evoked potential changes can be better understood. More extensive use of these tools in human and animal toxicology is needed to better understand the ability of this methodology to detect sensory changes, and to predict human toxicity from animal data.