Record Display for the EPA National Library Catalog


Main Title Acute Sulfolane Exposure Produces Temperature-Independent and Dependent Changes in Visual Evoked Potentials.
Author Dyer, R. S. ; Boyes, W. K. ; Hetzler, B. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/337;
Stock Number PB87-180006
Additional Subjects Nervous system disorders ; Visual perception ; Toxicity ; Exposure ; Organic solvents ; Toxicology ; Convulsive disorders ; Behavior disorders ; Hypothermia ; Rats ; Reprints ; Sulfolane ; Tetrahydrothiophene-1 ; 1-dioxide ; FEP(Flash Evoked Potentials) ; PREPS(Pattern Reversal Evoked Potentials)
Library Call Number Additional Info Location Last
NTIS  PB87-180006 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The report describes the consequences of acute exposure to sulfolane upon the visual system, as measured using flash evoked potential (FEPs) and pattern reversal evoked potentials (PREPs). A single injection of either 1/2 or 1/4, but not 1/8 the i.p. LD50 (1600 mg/kg) produced significant increases in peak latencies of both FEPs and PREPs. These effects of sulfolane were apparent within 1 hour and lasted longer than 6 hours. In addition, sulfolane produced an ambient temperature- and dose-dependent hypothermia. Attenuating hypothermia eliminated the effects of sulfolane on latencies. Amplitudes of FEP peaks to the first of a pair of stimuli were generally increased compared to control, and this effect was probably not temperature dependent. Sulfolane, therefore, produces effects on the visual system, some of which are temperature dependent.